Dr. Öğr. Üyesi Arjan KORTHOLT

1. Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson's disease

Athanasopoulos P. S., Memou A., Ho F. Y., Soliman A., Pots H., Papadopoulou V., et al.

The Biochemical journal , cilt.483, sa.6, ss.1097-1114, 2026 (SCI-Expanded, Scopus)

2. Taliglucerase Alfa Reduces Amyloid-β Burden by Restoring Autophagic Pathways in a Neuronal Model of Alzheimer’s Disease

Özkurt Ç., KÖSE S., KARASU Ç., KORTHOLT A., Kelicen-Uğur P.

Neurochemical Research , cilt.51, sa.3, 2026 (SCI-Expanded, Scopus)

3. Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction

Sabogal-Guáqueta A. M., Marmolejo-Garza A., Trombetta-Lima M., Oun A., Hunneman J., Chen T., et al.

Nature Communications , cilt.14, sa.1, 2023 (SCI-Expanded, Scopus)

4. Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization

Pathak P., Alexander K. K., Helton L. G., Kentros M., LeClair T. J., Zhang X., et al.

ACS Chemical Neuroscience , cilt.14, sa.11, ss.1971-1980, 2023 (SCI-Expanded, Scopus)

5. LRRK2 Structure-Based Activation Mechanism and Pathogenesis

Zhang X., Kortholt A.

BIOMOLECULES , cilt.13, sa.4, 2023 (SCI-Expanded, Scopus)

6. Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

Oun A., Hoeksema E., Soliman A., Brouwer F., Garcia-Reyes F., Pots H., et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , cilt.24, sa.2, 2023 (SCI-Expanded, Scopus)

7. LRRK2 protects immune cells against erastin-induced ferroptosis

Oun A., Soliman A., Trombetta-Lima M., Tzepapadaki A., Tsagkari D., Kortholt A., et al.

Neurobiology of Disease , cilt.175, 2022 (SCI-Expanded, Scopus)

8. The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids

Oun A., Sabogal-Guaqueta A. M., Galuh S., Alexander A., Kortholt A., Dolga A. M.

NEUROBIOLOGY OF DISEASE , cilt.173, 2022 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

9. Potential of Whole-Body Vibration in Parkinson's Disease: A Systematic Review and Meta-Analysis of Human and Animal Studies

Arauz Y. L. A., Ahuja G., Kamsma Y. P. T., Kortholt A., van der Zee E. A., van Heuvelen M. J. G.

BIOLOGY-BASEL , cilt.11, sa.8, 2022 (SCI-Expanded, Scopus)

10. Editorial: LRRK2-Fifteen Years From Cloning to the Clinic

Rideout H., Greggio E., Kortholt A., Nichols R. J.

FRONTIERS IN NEUROSCIENCE , cilt.16, 2022 (SCI-Expanded, Scopus)

11. A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Marchand A., Sarchione A., Athanasopoulos P. S., Bauderlique-Le Roy H., Goveas L., Magnez R., et al.

CELLS , cilt.11, sa.6, 2022 (SCI-Expanded, Scopus)

12. Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

Singh R. K., Soliman A., Guaitoli G., Stoermer E., von Zweydorf F., Dal Maso T., et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , cilt.119, sa.9, 2022 (SCI-Expanded, Scopus)

13. The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation

Cogo S., Ho F. Y., Tosoni E., Tomkins J. E., Tessari I., Iannotta L., et al.

BRAIN RESEARCH , cilt.1778, 2022 (SCI-Expanded, Scopus)

14. The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats

CANKARA F. N., Kus M. S., Gunaydin C., Safak S., BİLGE S. S., ÖZMEN Ö., et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY , cilt.44, sa.2, ss.168-177, 2022 (SCI-Expanded, Scopus)

15. Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides

Helton L. G., Soliman A., von Zweydorf F., Kentros M., Manschwetus J. T., Hall S., et al.

ACS CHEMICAL BIOLOGY , cilt.16, sa.11, ss.2326-2338, 2021 (SCI-Expanded, Scopus)

16. Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

van Haastert P. J. M., Keizer-Gunnink I., Pots H., Ortiz-Mateos C., Veltman D., van Egmond W., et al.

MOLECULAR BIOLOGY OF THE CELL , cilt.32, sa.20, 2021 (SCI-Expanded, Scopus)

17. A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity

Rosenbusch K. E., Oun A., Sanislav O., Lay S. T., Keizer-Gunnink I., Annesley S. J., et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , cilt.9, 2021 (SCI-Expanded, Scopus)

18. LRRK2 Targeting Strategies as Potential Treatment of Parkinson's Disease

Wojewska D. N., Kortholt A.

BIOMOLECULES , cilt.11, sa.8, 2021 (SCI-Expanded, Scopus)

19. Combined FCS and PCH Analysis to Quantify Protein Dimerization in Living Cells

Nederveen-Schippers L. M., Pathak P., Keizer-Gunnink I., Westphal A. H., van Haastert P. J. M., Borst J. W., et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , cilt.22, sa.14, 2021 (SCI-Expanded, Scopus)

20. Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range

Xu X., Bhimani S., Pots H., Wen X., Jeon T. J., Kortholt A., et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , cilt.9, 2021 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

21. The tale of proteolysis targeting chimeras (PROTACs) for Leucine-Rich Repeat Kinase 2 (LRRK2)

Konstantinidou M., Oun A., Pathak P., Zhang B., Wang Z., ter Brake F., et al.

CHEMMEDCHEM , cilt.16, sa.6, ss.959-965, 2021 (SCI-Expanded, Scopus)

22. The neuroprotective action of lenalidomide on rotenone model of Parkinson's Disease: Neurotrophic and supportive actions in the substantia nigra pars compacta

CANKARA F. N., Gunaydin C., BİLGE S. S., ÖZMEN Ö., Kortholt A.

NEUROSCIENCE LETTERS , cilt.738, 2020 (SCI-Expanded, Scopus)

23. Allosteric inhibition of LRRK2, where are we now

Soliman A., CANKARA F. N., Kortholt A.

BIOCHEMICAL SOCIETY TRANSACTIONS , cilt.48, sa.5, ss.2185-2194, 2020 (SCI-Expanded, Scopus)

24. Complex Analysis of Fluorescence Intensity Fluctuations of Molecular Compounds

Yatskou M. M., Skakun V. V., Nederveen-Schippers L., Kortholt A., Apanasovich V. V.

JOURNAL OF APPLIED SPECTROSCOPY , cilt.87, sa.4, ss.685-692, 2020 (SCI-Expanded, Scopus)

25. Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria

Buckley C. M., Pots H., Gueho A., Vines J. H., Munn C. J., Phillips B. A., et al.

CURRENT BIOLOGY , cilt.30, sa.15, ss.2912-2931, 2020 (SCI-Expanded, Scopus)

26. Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

Leemans M., Galicia C., Deyaert E., Daems E., Krause L., Paesmans J., et al.

BIOCHEMICAL JOURNAL , cilt.477, sa.7, ss.1203-1218, 2020 (SCI-Expanded, Scopus)

27. Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity

Maria Sabogal-Guaqueta A., Hobbie F., Keerthi A., Oun A., Kortholt A., Boddeke E., et al.

BIOMEDICINE & PHARMACOTHERAPY , cilt.118, 2019 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

28. Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

Deyaert E., Leemans M., Singh R. K., Gallardo R., Steyaert J., Kortholt A., et al.

BIOCHEMICAL JOURNAL , cilt.476, ss.51-66, 2019 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

29. Roco Proteins: GTPases with a Baroque Structure and Mechanism

Wauters L., Versees W., Kortholt A.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , cilt.20, sa.1, 2019 (SCI-Expanded, Scopus)

30. Biochemical and kinetic properties of the complex Roco G-protein cycle

Wauters L., Terheyden S., Gilsbach B. K., Leemans M., Athanasopoulos P. S., Guaitoli G., et al.

BIOLOGICAL CHEMISTRY , cilt.399, sa.12, ss.1447-1456, 2018 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

31. The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

Athanasopoulos P. S., Heumann R., Kortholt A.

BIOLOGICAL CHEMISTRY , cilt.399, sa.7, ss.643-647, 2018 (SCI-Expanded, Scopus)

32. The cytoskeleton regulates symmetry transitions in moving amoeboid cells

van Haastert P. J. M., Keizer-Gunnink I., Kortholt A.

JOURNAL OF CELL SCIENCE , cilt.131, sa.7, 2018 (SCI-Expanded, Scopus)

33. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis

Xu X., Wen X., Veltman D. M., Keizer-Gunnink I., Pots H., Kortholt A., et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , cilt.114, sa.47, 2017 (SCI-Expanded, Scopus)

34. A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

Deyaert E., Wauters L., Guaitoli G., Konijnenberg A., Leemans M., Terheyden S., et al.

NATURE COMMUNICATIONS , cilt.8, 2017 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

35. The LRR-Roc-COR module of the Chlorobium tepidum Roco protein: crystallization and X-ray crystallographic analysis

Deyaert E., Kortholt A., Versees W.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS , cilt.73, ss.520-524, 2017 (SCI-Expanded, Scopus)

36. Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

van Haastert P. J. M., Keizer-Gunnink I., Kortholt A.

MOLECULAR BIOLOGY OF THE CELL , cilt.28, sa.7, ss.922-934, 2017 (SCI-Expanded, Scopus)

37. The unconventional G-protein cycle of LRRK2 and Roco proteins

Terheyden S., Nederveen-Schippers L. M., Kortholt A.

BIOCHEMICAL SOCIETY TRANSACTIONS , cilt.44, ss.1611-1616, 2016 (SCI-Expanded, Scopus)

38. Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Guaitoli G., Raimondi F., Gilsbach B. K., Gomez-Llorente Y., Deyaert E., Renzi F., et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , cilt.113, sa.30, 2016 (SCI-Expanded, Scopus)

39. A G alpha-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis

Liu Y., Lacal J., Veltman D. M., Fusetti F., van Haastert P. J. M., Firtel R. A., et al.

DEVELOPMENTAL CELL , cilt.37, sa.5, ss.458-472, 2016 (SCI-Expanded, Scopus)

40. A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

Skoge M., Wong E., Hamza B., Bae A., Martel J., Kataria R., et al.

PLOS ONE , cilt.11, sa.6, 2016 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

41. The small GTPases Ras and Rap1 bind to and control TORC2 activity

Khanna A., Lotfi P., Chavan A. J., Montano N. M., Bolourani P., Weeks G., et al.

SCIENTIFIC REPORTS , cilt.6, 2016 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

42. Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease

Rosenbusch K. E., Kortholt A.

PARKINSONS DISEASE , cilt.2016, 2016 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

43. Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

Plak K., Pots H., Van Haastert P. J. M., Kortholt A.

BMC CELL BIOLOGY , cilt.17, 2016 (SCI-Expanded)

44. Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

Kamp M. E., Liu Y., Kortholt A.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , cilt.17, sa.1, 2016 (SCI-Expanded, Scopus)

45. Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations

Rudi K., Ho F. Y., Gilsbach B. K., Pots H., Wittinghofer A., Kortholt A., et al.

BIOSCIENCE REPORTS , cilt.35, 2015 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

46. Structural Characterization of LRRK2 Inhibitors

Gilsbach B. K., Messias A. C., Ito G., Sattler M., Alessi D. R., Wittinghofer A., et al.

JOURNAL OF MEDICINAL CHEMISTRY , cilt.58, sa.9, ss.3751-3756, 2015 (SCI-Expanded, Scopus)

47. Homer3 regulates the establishment of neutrophil polarity

Wu J., Pipathsouk A., Keizer-Gunnink A., Fusetti F., Alkema W., Liu S., et al.

MOLECULAR BIOLOGY OF THE CELL , cilt.26, sa.9, ss.1629-1639, 2015 (SCI-Expanded, Scopus)

48. A G alpha stimulated Ras/Rap switch regulates Dictyostelium chemotaxis.

Lacal J., Liu Y., Veltman D. M., Keizer-Gunnink I., Fusetti F., van Haastert P. J., et al.

MOLECULAR BIOLOGY OF THE CELL , cilt.26, 2015 (SCI-Expanded, Scopus)

49. Revisiting the Roco G-protein cycle

Terheyden S., Ho F. Y., Gilsbach B. K., Wittinghofer A., Kortholt A.

BIOCHEMICAL JOURNAL , cilt.465, ss.139-147, 2015 (SCI-Expanded, Scopus)

50. Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

Plak K., Keizer-Gunnink I., van Haastert P. J. M., Kortholt A.

MOLECULAR BIOLOGY OF THE CELL , cilt.25, sa.25, ss.4195-4204, 2014 (SCI-Expanded, Scopus)

51. Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

Gilsbach B. K., Kortholt A.

FRONTIERS IN MOLECULAR NEUROSCIENCE , cilt.7, 2014 (SCI-Expanded, Scopus)

52. Ras activation and symmetry breaking during Dictyostelium chemotaxis

Kortholt A., Keizer-Gunnink I., Kataria R., Van Haastert P. J. M.

JOURNAL OF CELL SCIENCE , cilt.126, sa.19, ss.4502-4513, 2013 (SCI-Expanded, Scopus)

53. Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis

Kataria R., van Haastert P. J. M., Kortholt A.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , cilt.110, sa.34, 2013 (SCI-Expanded, Scopus)

54. Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

Kataria R., Xu X., Fusetti F., Keizer-Gunnink I., Jin T., van Haastert P. J. M., et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , cilt.110, sa.16, ss.6424-6429, 2013 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

55. Simple system - substantial share: The use of Dictyosrelium in cell biology and molecular medicine

Mueller-Taubenberger A., Kortholt A., Eichinger L.

EUROPEAN JOURNAL OF CELL BIOLOGY , cilt.92, sa.2, ss.45-53, 2013 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

56. Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

Koelsch V., Shen Z., Lee S., Plak K., Lotfi P., Chang J., et al.

MOLECULAR BIOLOGY OF THE CELL , cilt.24, sa.2, ss.100-114, 2013 (SCI-Expanded, Scopus)

57. GxcC connects Rap and Rac signaling during Dictyostelium development

Plak K., Veltman D., Fusetti F., Beeksma J., Rivero F., Van Haastert P. J. M., et al.

BMC CELL BIOLOGY , cilt.14, 2013 (SCI-Expanded)

58. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

Gilsbach B. K., Ho F. Y., Vetter I. R., van Haastert P. J. M., Wittinghofer A., Kortholt A.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , cilt.109, sa.26, ss.10322-10327, 2012 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma