LRRK2 Targeting Strategies as Potential Treatment of Parkinson's Disease
BIOMOLECULES, cilt.11, sa.8, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 11 Sayı: 8
- Basım Tarihi: 2021
- Doi Numarası: 10.3390/biom11081101
- Dergi Adı: BIOMOLECULES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
- Anahtar Kelimeler: kinase inhibitors, neurodegenerative diseases, Parkinson's disease, protein-protein interactions, small GTPases, LRRK2, KINASE-ACTIVITY, STRUCTURAL-CHARACTERIZATION, BRAIN PENETRANT, HIGHLY POTENT, INHIBITORS, DISCOVERY, BINDING, DOMAIN, DESIGN, LOCALIZATION
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Parkinson's Disease (PD) affects millions of people worldwide with no cure to halt the progress of the disease. Leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of PD and, as such, LRRK2 inhibitors are promising therapeutic agents. In the last decade, great progress in the LRRK2 field has been made. This review provides a comprehensive overview of the current state of the art, presenting recent developments and challenges in developing LRRK2 inhibitors, and discussing extensively the potential targeting strategies from the protein perspective. As currently there are three LRRK2-targeting agents in clinical trials, more developments are predicted in the upcoming years.