Highlighting the role of Ras and Rap during Dictyostelium chemotaxis
CELLULAR SIGNALLING, cilt.20, sa.8, ss.1415-1422, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 20 Sayı: 8
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.cellsig.2008.02.006
- Dergi Adı: CELLULAR SIGNALLING
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1415-1422
- Anahtar Kelimeler: Dictyostelium, chemotaxis, Ras, Rap, guanine exchange factor, GTP-binding protein, RECEPTOR-MEDIATED ACTIVATION, HETEROTRIMERIC G-PROTEINS, CONTROLS CELL-ADHESION, BETA-GAMMA-SUBUNITS, HEAVY-CHAIN KINASE, ADENYLYL-CYCLASE, SIGNAL-TRANSDUCTION, PHOSPHOLIPASE-C, MYOSIN-II, CHEMOATTRACTANT RECEPTORS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.