Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells
BMC CELL BIOLOGY, cilt.17, 2016 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17
- Basım Tarihi: 2016
- Doi Numarası: 10.1186/s12860-015-0078-0
- Dergi Adı: BMC CELL BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Anahtar Kelimeler: Rap, talin, Dictyostelium, Adhesion, Chemotaxis, Development, INTEGRIN ACTIVATION, RAS, MORPHOGENESIS, BINDING, DISCOIDEUM, EFFECTOR, MOTILITY, POLARITY, KINASE, DOMAIN
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Background: The small G-protein Rap1 is an important regulator of cellular adhesion in Dictyostelium, however so far the downstream signalling pathways for cell adhesion are not completely characterized. In mammalian cells talin is crucial for adhesion and Rap1 was shown to be a key regulator of talin signalling.