Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells


Plak K., Pots H., Van Haastert P. J. M. , Kortholt A.

BMC CELL BIOLOGY, vol.17, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2016
  • Doi Number: 10.1186/s12860-015-0078-0
  • Journal Name: BMC CELL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded
  • Keywords: Rap, talin, Dictyostelium, Adhesion, Chemotaxis, Development, INTEGRIN ACTIVATION, RAS, MORPHOGENESIS, BINDING, DISCOIDEUM, EFFECTOR, MOTILITY, POLARITY, KINASE, DOMAIN

Abstract

Background: The small G-protein Rap1 is an important regulator of cellular adhesion in Dictyostelium, however so far the downstream signalling pathways for cell adhesion are not completely characterized. In mammalian cells talin is crucial for adhesion and Rap1 was shown to be a key regulator of talin signalling.