GxcC connects Rap and Rac signaling during Dictyostelium development
BMC CELL BIOLOGY, cilt.14, 2013 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14
- Basım Tarihi: 2013
- Doi Numarası: 10.1186/1471-2121-14-6
- Dergi Adı: BMC CELL BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Anahtar Kelimeler: Rap, Rac, GEF, Development, Dictyostelium, GTP-BINDING PROTEINS, CELL-ADHESION, MORPHOGENESIS, SUPERFAMILY, CHEMOTAXIS, DISCOIDEUM, FAMILY
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Background: Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces pseudopod formation by activating PI3K and it regulates substrate attachment and myosin disassembly via the serine/threonine kinase Phg2. RapA is also important in late development, however so far little is known about the downstream effectors of RapA that play a role in this process.