GxcC connects Rap and Rac signaling during Dictyostelium development

Plak K., Veltman D., Fusetti F., Beeksma J., Rivero F., Van Haastert P. J. M., ...More

BMC CELL BIOLOGY, vol.14, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2013
  • Doi Number: 10.1186/1471-2121-14-6
  • Journal Name: BMC CELL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Keywords: Rap, Rac, GEF, Development, Dictyostelium, GTP-BINDING PROTEINS, CELL-ADHESION, MORPHOGENESIS, SUPERFAMILY, CHEMOTAXIS, DISCOIDEUM, FAMILY
  • Süleyman Demirel University Affiliated: No

Abstract

Background: Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces pseudopod formation by activating PI3K and it regulates substrate attachment and myosin disassembly via the serine/threonine kinase Phg2. RapA is also important in late development, however so far little is known about the downstream effectors of RapA that play a role in this process.