Crepis foetida L. subsp rhoeadifolia (Bleb.) Celak. as a source of multifunctional agents: Cytotoxic and phytochemical evaluation

Zengin G., Sarikurkcu C., UYAR P., Aktumsek A., Uysal S., Kocak M. S. , ...More

JOURNAL OF FUNCTIONAL FOODS, vol.17, pp.698-708, 2015 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jff.2015.06.041
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.698-708


The cytotoxic, anticholinesterase, antityrosinase and antioxidant effects of methanol extract from the flower of C. foetida subsp. rhoeadifolia (CFRME) were evaluated. The cytotoxic effect was investigated using HepG2, Caco-2, MCF-7 and MCF-10A cell lines. Enzyme inhibitory activities were tested by spectrophotometric methods. Different chemical assays were used to determine the antioxidant effects. In addition, phenolic constituents were quantified. High-performance liquid chromatographic (HPLC) analysis revealed that chlorogenic acid was the major phenolic component in the extract. The extract showed a strong antiproliferative, antioxidant, and anticholinesterase and antityrosinase effects. These findings suggest that C. foetida subsp. rhoeadifolia may be considered as a source of ingredients that can be used as food supplements. (C) 2015 Elsevier Ltd. All rights reserved.