Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1 alpha pathway

AŞCI, Halil; SAYGIN, Mustafa; YEŞİLOT, Sukriye; Topsakal, Senay; CANKARA, Fatma; Ozmen, Ozlem; Savran, Mehtap

doi:10.5152/anatoljcardiol.2015.6418

Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1 alpha pathway

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AŞCI H. , SAYGIN M. , YEŞİLOT S., Topsakal S., CANKARA F. N. , Ozmen O., ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.16, no.9, pp.648-654, 2016 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 16 Issue: 9
Publication Date: 2016
Doi Number: 10.5152/anatoljcardiol.2015.6418
Title of Journal : ANATOLIAN JOURNAL OF CARDIOLOGY
Page Numbers: pp.648-654
Keywords: corn syrup, cardiac damage, ST-1, HIF-1 alpha, caspase-3, oxidative stress, INSULIN-RESISTANCE, URIC-ACID, FRUCTOSE, EXPRESSION, HYPOXIA, HEART, RATS, HYPERURICEMIA, INFLAMMATION, DYSFUNCTION

Abstract

Objective: The aim of this study was to investigate the protective effects of aspirin (AS) and vitamin C (VC) against cardiac damage induced by chronic corn syrup (CS) consumption via a mechanism involving sirtuin-1 (ST-1), hypoxia-inducible factor-1 alpha (HIF-1 alpha), and the caspase-3 pathway in rats.