Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1 alpha pathway


AŞCI H. , SAYGIN M. , YEŞİLOT S., Topsakal S., CANKARA F. N. , Ozmen O., ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.16, no.9, pp.648-654, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.5152/anatoljcardiol.2015.6418
  • Title of Journal : ANATOLIAN JOURNAL OF CARDIOLOGY
  • Page Numbers: pp.648-654
  • Keywords: corn syrup, cardiac damage, ST-1, HIF-1 alpha, caspase-3, oxidative stress, INSULIN-RESISTANCE, URIC-ACID, FRUCTOSE, EXPRESSION, HYPOXIA, HEART, RATS, HYPERURICEMIA, INFLAMMATION, DYSFUNCTION

Abstract

Objective: The aim of this study was to investigate the protective effects of aspirin (AS) and vitamin C (VC) against cardiac damage induced by chronic corn syrup (CS) consumption via a mechanism involving sirtuin-1 (ST-1), hypoxia-inducible factor-1 alpha (HIF-1 alpha), and the caspase-3 pathway in rats.