Protective effects of aspirin and vitamin C against corn syrup consumption-induced cardiac damage through sirtuin-1 and HIF-1 alpha pathway
ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.16, sa.9, ss.648-654, 2016 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 9
- Basım Tarihi: 2016
- Doi Numarası: 10.5152/anatoljcardiol.2015.6418
- Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.648-654
- Anahtar Kelimeler: corn syrup, cardiac damage, ST-1, HIF-1 alpha, caspase-3, oxidative stress, INSULIN-RESISTANCE, URIC-ACID, FRUCTOSE, EXPRESSION, HYPOXIA, HEART, RATS, HYPERURICEMIA, INFLAMMATION, DYSFUNCTION
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to investigate the protective effects of aspirin (AS) and vitamin C (VC) against cardiac damage induced by chronic corn syrup (CS) consumption via a mechanism involving sirtuin-1 (ST-1), hypoxia-inducible factor-1 alpha (HIF-1 alpha), and the caspase-3 pathway in rats.