Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats

Fidan H., Sahin O., Yavuz Y., Kilbas A., Cetinkaya Z., Ela Y., ...More

CRITICAL CARE MEDICINE, vol.35, no.12, pp.2822-2829, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 12
  • Publication Date: 2007
  • Doi Number: 10.1097/01.ccm.0000295588.86982.7d
  • Title of Journal : CRITICAL CARE MEDICINE
  • Page Numbers: pp.2822-2829


Objective: Sepsis and ensuing multiorgan failure continue to be the major causes of mortality in intensive care units. Nuclear factor (NF)-kappa B activation is supposed to be one of the targets in the treatment of sepsis. We studied the effectiveness of caffeic phenethyl ester (CAPE), a known NF-kappa B inhibitor, in cecal ligation and puncture (CLP)-induced sepsis and lung injury.