Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats

Fidan H., Sahin O., Yavuz Y., Kilbas A., Cetinkaya Z., Ela Y., ...Daha Fazla

CRITICAL CARE MEDICINE, cilt.35, sa.12, ss.2822-2829, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Objective: Sepsis and ensuing multiorgan failure continue to be the major causes of mortality in intensive care units. Nuclear factor (NF)-kappa B activation is supposed to be one of the targets in the treatment of sepsis. We studied the effectiveness of caffeic phenethyl ester (CAPE), a known NF-kappa B inhibitor, in cecal ligation and puncture (CLP)-induced sepsis and lung injury.