Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats


GÜLMEN Ş. , Kiris I. , NARİN C., Ceylan B. G. , Mermi B., Sutcu R., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.157, sa.1, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 157 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.jss.2008.08.011
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH

Özet

Background. Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. Endothelin (ET) is involved in the development of renal injury induced by aortic IR and tezosentan (R0 61-0612) is a specific ET receptor antagonist. The aim of this study was to examine the effect of tezosentan on renal injury induced by abdominal aortic IR in rats.