Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

GÜLMEN, Şenol; Kiris, İlker; NARİN, CÜNEYT; Ceylan, Berit; Mermi, Betul; Sutcu, Recep; METEOĞLU, İBRAHİM

doi:10.1016/j.jss.2008.08.011

Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

GÜLMEN Ş., Kiris I., NARİN C., Ceylan B. G., Mermi B., Sutcu R., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.157, sa.1, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 157 Sayı: 1
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.jss.2008.08.011
Dergi Adı: JOURNAL OF SURGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Background. Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. Endothelin (ET) is involved in the development of renal injury induced by aortic IR and tezosentan (R0 61-0612) is a specific ET receptor antagonist. The aim of this study was to examine the effect of tezosentan on renal injury induced by abdominal aortic IR in rats.