Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

GÜLMEN, Şenol; Kiris, İlker; NARİN, CÜNEYT; Ceylan, Berit; Mermi, Betul; Sutcu, Recep; METEOĞLU, İBRAHİM

doi:10.1016/j.jss.2008.08.011

Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

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GÜLMEN Ş. , Kiris I. , NARİN C., Ceylan B. G. , Mermi B., Sutcu R., ...More

JOURNAL OF SURGICAL RESEARCH, vol.157, no.1, 2009 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 157 Issue: 1
Publication Date: 2009
Doi Number: 10.1016/j.jss.2008.08.011
Title of Journal : JOURNAL OF SURGICAL RESEARCH

Abstract

Background. Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. Endothelin (ET) is involved in the development of renal injury induced by aortic IR and tezosentan (R0 61-0612) is a specific ET receptor antagonist. The aim of this study was to examine the effect of tezosentan on renal injury induced by abdominal aortic IR in rats.