Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats


GÜLMEN Ş. , Kiris I. , NARİN C., Ceylan B. G. , Mermi B., Sutcu R., ...More

JOURNAL OF SURGICAL RESEARCH, vol.157, no.1, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 157 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.08.011
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH

Abstract

Background. Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. Endothelin (ET) is involved in the development of renal injury induced by aortic IR and tezosentan (R0 61-0612) is a specific ET receptor antagonist. The aim of this study was to examine the effect of tezosentan on renal injury induced by abdominal aortic IR in rats.