Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia

ERDEMOĞLU, Evrim; GÜNEY, Mehmet; Giray, Seren; Take, Guelnur; Mungan, Tamer

doi:10.1016/j.ejogrb.2009.04.034

Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia

ERDEMOĞLU E. , GÜNEY M., Giray S. G. , Take G., Mungan T.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.145, no.2, pp.195-199, 2009 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 145 Issue: 2
Publication Date: 2009
Doi Number: 10.1016/j.ejogrb.2009.04.034
Title of Journal : EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Page Numbers: pp.195-199

Abstract

Objective: The effects of metformin on S6K1, which is a crucial effector of mTOR signaling, and on endometrium were studied in a mouse model of endometrial hyperplasia induced by unopposed estradiol or tamoxifen.