Synthesis of new calix[4] arene amide derivatives and investigation of their DNA cleavage activity

Ozkan S. C. , Yilmaz A., ÖZMEN İ.

SUPRAMOLECULAR CHEMISTRY, cilt.26, sa.1, ss.25-31, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 26 Konu: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/10610278.2013.817578
  • Dergi Adı: SUPRAMOLECULAR CHEMISTRY
  • Sayfa Sayıları: ss.25-31

Özet

This study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, H-1 NMR, C-13 NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III.