Serum zonulin and claudin-5 levels in patients with bipolar disorder

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Kılıç F., Işık Ü., Demirdaş A., Doğuç D., Bozkurt M.

JOURNAL OF AFFECTIVE DISORDERS, cilt.266, ss.37-42, 2020 (SCI-Expanded, SSCI, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 266
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jad.2020.01.117
  • Dergi Adı: JOURNAL OF AFFECTIVE DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, AgeLine, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.37-42
  • Anahtar Kelimeler: Bipolar Disorder, Blood-Brain Barrier, Claudin-5, Intestinal Permeability, Zonulin, INTESTINAL PERMEABILITY, FECAL MICROBIOTA, CLDN5 LOCUS, SCHIZOPHRENIA
  • Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Background: The etiology in bipolar disorder has not been fully understanding. There are limited data regarding the relationship between the permeability of intestinal and blood-brain barrier (BBB), and bipolar disorder etiology. Zonulin is regarded as a non-invasive biomarker for intestinal permeability. Claudin-5 is an important part of BBB permeability. In this study, we assumed that there may be a deterioration in serum zonulin and claudin-5 levels in patients with bipolar disorder and this may affect the severity of the disease.