JOURNAL OF AFFECTIVE DISORDERS, vol.266, pp.37-42, 2020 (SCI-Expanded)
Article / Article
JOURNAL OF AFFECTIVE DISORDERS
Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, AgeLine, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
Bipolar Disorder, Blood-Brain Barrier, Claudin-5, Intestinal Permeability, Zonulin, INTESTINAL PERMEABILITY, FECAL MICROBIOTA, CLDN5 LOCUS, SCHIZOPHRENIA
Süleyman Demirel University Affiliated:
Background: The etiology in bipolar disorder has not been fully understanding. There are limited data regarding the relationship between the permeability of intestinal and blood-brain barrier (BBB), and bipolar disorder etiology. Zonulin is regarded as a non-invasive biomarker for intestinal permeability. Claudin-5 is an important part of BBB permeability. In this study, we assumed that there may be a deterioration in serum zonulin and claudin-5 levels in patients with bipolar disorder and this may affect the severity of the disease.