Serum zonulin and claudin-5 levels in patients with bipolar disorder

Creative Commons License

Kılıç F., Işık Ü., Demirdaş A., Doğuç D., Bozkurt M.

JOURNAL OF AFFECTIVE DISORDERS, vol.266, pp.37-42, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 266
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jad.2020.01.117
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, AgeLine, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.37-42
  • Keywords: Bipolar Disorder, Blood-Brain Barrier, Claudin-5, Intestinal Permeability, Zonulin, INTESTINAL PERMEABILITY, FECAL MICROBIOTA, CLDN5 LOCUS, SCHIZOPHRENIA
  • Süleyman Demirel University Affiliated: Yes


Background: The etiology in bipolar disorder has not been fully understanding. There are limited data regarding the relationship between the permeability of intestinal and blood-brain barrier (BBB), and bipolar disorder etiology. Zonulin is regarded as a non-invasive biomarker for intestinal permeability. Claudin-5 is an important part of BBB permeability. In this study, we assumed that there may be a deterioration in serum zonulin and claudin-5 levels in patients with bipolar disorder and this may affect the severity of the disease.