The Role of Inflammation in Preeclampsia

Sezik M.

21st European Congress of Perinatal Medicine, İstanbul, Turkey, 10 - 13 September 2008, pp.389-392 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.389-392


Preeclampsia is a syndrome with exaggeration of physiological systemic inflammation of pregnancy. Placenta seems to be the initial stimulus for activation of systemic inflammation. However, the presence of pre-pregnancy chronic inflammation is also a determining factor. This could explain why women with pre-existing hypertension, insulin resistance and increased body-mass index have increased risks of preeclampsia and vice versa. Investigations on limiting the inflammatory response by treating maternal infections or novel anti-inflammatory interventions to reduce the incidence or severity of preeclampsia are warranted.