The role of immunohistochemical adrenomedullin and Bcl-2 expression in development of type-1 endometrial adenocarcinoma Adrenomedullin expression in endometrium
PATHOLOGY RESEARCH AND PRACTICE, vol.212, no.5, pp.450-455, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 212 Issue: 5
- Publication Date: 2016
- Doi Number: 10.1016/j.prp.2016.02.021
- Journal Name: PATHOLOGY RESEARCH AND PRACTICE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.450-455
- Süleyman Demirel University Affiliated: Yes
Abstract
Background: Adrenomedullin (AM) is a pluripotent peptide first discovered from human pheochromocytoma. AM expression has been shown in various cancer types including endometrium cancer. Bcl-2 is an antiapoptotic protein which might be regulated by AM in hypoxic conditions. The aim of the present study was to investigate the role of AM and Bcl-2 expressions in carcinogenesis of type-1 endometrium cancer.