High-pressure die casting (HPDC) is widely used to manufacture nonferrous castings for the automotive industry. HPDC products' properties, such as strength, porosity shape and size, heat conductivity, and microstructure, vary with changes in process parameters, such as vacuum, casting temperature, pressure, velocity, cooling, and die quality. This study contributes to the literature by determining the effect of pouring temperatures, casting pressures, velocity, and vacuum application inside the die cavity on the mechanical and metallurgical properties of A380 aluminum alloy. As a result, 3-5 % increases in tensile and yield stress and a 10-13 % decrease in grain sizes were observed with vacuum inside the die cavity. Also, increasing the injection pressure from 100 to 200 bar under non-vacuum conditions improved the mechanical strength of the alloy, and increasing the pouring temperature from 740 to 800 degrees C caused the pressure die-cast A380 alloy to adopt an inhomogeneous structure.