Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

Sahin M., Isler M., Senol A., Demirci M., Aydin Z. D.

WORLD JOURNAL OF GASTROENTEROLOGY, vol.11, no.48, pp.7688-7689, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 48
  • Publication Date: 2005
  • Doi Number: 10.3748/wjg.v11.i48.7688
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.7688-7689


Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fascioliasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.