Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

Sahin M. , Isler M., Senol A. , Demirci M., Aydin Z. D.

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.11, sa.48, ss.7688-7689, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Konu: 48
  • Basım Tarihi: 2005
  • Doi Numarası: 10.3748/wjg.v11.i48.7688
  • Sayfa Sayıları: ss.7688-7689


Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fascioliasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.