Hemophagocytic syndrome: A rare life-threatening complication of visceral leishmaniasis in a young boy

Tunc B., Ayata A.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.18, no.8, pp.531-536, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 8
  • Publication Date: 2001
  • Doi Number: 10.1080/088800101753328501
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.531-536


The authors report a case of hemophagocytic syndrome (HPS) associated with acute visceral leishmaniasis (VL). A 4-year-old boy was admitted with high fever; hepatosplenomegaly, aped pancytopenia. Elevated serum ferritin and triglyceride, low fibrinogen levels, and bone-marrow (BM) histiocytic hyperplasia with prominent hemophagocytosis were consistent with a HPS. An initial diagnosis of kala-azar was refitted because of negativity of BM aspiration find serology for this parasite, and the diagnosis Of HPS Was made. Three months after first admission, reevaluation of the BM aspiration revealed many amastigotes of Leishmania parasites. The serology of VL became positive, finally establishing the diagnosis of VL. Although specific therapy for VL was instituted, the patient died 4 weeks after the diagnosis.