Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia


Takir M., Kostek O., Ozkok A., ELÇİOĞLU Ö. C. , Bakan A., Erek A., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.63, no.8, pp.924-929, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1097/jim.0000000000000242
  • Title of Journal : JOURNAL OF INVESTIGATIVE MEDICINE
  • Page Numbers: pp.924-929

Abstract

Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.