EVALUATION OF THE EFFECT OF ACETAMINOPHEN AT DIFFERENT DOSES ON HEPATIC NITRIC OXIDE SYNTHASE ENZYME BY USING IMMUNOHISTOCHEMICAL AND BIOCHEMICAL METHODS


Kocak A., GÖKÇİMEN A., Yilmaz N., Vural H.

NOBEL MEDICUS, vol.7, no.2, pp.88-95, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2011
  • Title of Journal : NOBEL MEDICUS
  • Page Numbers: pp.88-95

Abstract

Objective: Excessive administration of acetaminophen have some negative effects on liver that may even progress to acute failure. It has been reported that some metabolites produced in liver parenchyme may also contribute to this process. Nitric oxide (NO) is a highly reactive substance which is synthesized in response to inflammatory mediators.