EVALUATION OF THE EFFECT OF ACETAMINOPHEN AT DIFFERENT DOSES ON HEPATIC NITRIC OXIDE SYNTHASE ENZYME BY USING IMMUNOHISTOCHEMICAL AND BIOCHEMICAL METHODS


Kocak A., GÖKÇİMEN A., Yilmaz N., Vural H.

NOBEL MEDICUS, vol.7, no.2, pp.88-95, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2011
  • Journal Name: NOBEL MEDICUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.88-95
  • Süleyman Demirel University Affiliated: Yes

Abstract

Objective: Excessive administration of acetaminophen have some negative effects on liver that may even progress to acute failure. It has been reported that some metabolites produced in liver parenchyme may also contribute to this process. Nitric oxide (NO) is a highly reactive substance which is synthesized in response to inflammatory mediators.