The evaluation of Nesfatin-1 levels in patients with OSAS associated with metabolic syndrome

Aksu O., AYDIN B., Doguc D. K. , İLHAN İ., ÖZTÜRK Ö., ALTUNTAŞ A., ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.38, no.4, pp.463-469, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1007/s40618-014-0216-0
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.463-469
  • Keywords: Obstructive sleep apnea syndrome, Metabolic syndrome, Nesfatin-1, OBSTRUCTIVE SLEEP-APNEA
  • Süleyman Demirel University Affiliated: Yes


Purpose The association of obstructive sleep apnea syndrome (OSAS) and metabolic syndrome (MS) has been demonstrated in studies and in recent years; the effect of OSAS on insulin resistance independent of the level of obesity is being investigated. Nesfatin-1 is a newly defined 82 amino acid protein with a precursor molecule of NUCB2 (nucleobindin 2). Nesfatin-1 is not only essential in regulation of food ingestion but also important in regulation of some brain functions, autonomic regulation, stress, mental state, and paradoxical sleep. We aimed to evaluate the relationship between OSAS and MS and the MS dependent or independent effect of Nesfatin-1 on this relationship.