Melatonin receptor agonist ramelteon alleviates experimental acute ocular inflammation via HIF-1 Alpha/VEGF/E-NOS signaling
EUROPEAN JOURNAL OF OPHTHALMOLOGY, cilt.33, sa.2, ss.1018-1025, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.1177/11206721221123878
- Dergi Adı: EUROPEAN JOURNAL OF OPHTHALMOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1018-1025
- Anahtar Kelimeler: Ramelteon, melatonin analog, endotoxin-induced uveitis, inflammation, HIF 1 alpha, ENDOTOXIN-INDUCED UVEITIS, NITRIC-OXIDE, EXPRESSION, RAT
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Purpose: Ramelteon (RML) is a potent, selective agonist of the high-affinity melatonin receptor 1 and 2 receptors. In addition, RML is known to have antioxidant and anti-inflammatory effects. In this study, we aimed to investigate the effects of RML on HIF-1 alpha, VEGF and e-NOS signaling pathway in a rat model of endotoxin-induced uveitis (EIU).