Melatonin receptor agonist ramelteon alleviates experimental acute ocular inflammation via HIF-1 Alpha/VEGF/E-NOS signaling


USTA SOFU G., ERZURUMLU Y., KARACA U., CANDAN İ. A. , SAVRAN M., AŞCI H., ...More

EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2022 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1177/11206721221123878
  • Journal Name: EUROPEAN JOURNAL OF OPHTHALMOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, CAB Abstracts, EMBASE, MEDLINE
  • Keywords: Ramelteon, melatonin analog, endotoxin-induced uveitis, inflammation, HIF 1 alpha, ENDOTOXIN-INDUCED UVEITIS, NITRIC-OXIDE, EXPRESSION, RAT

Abstract

Purpose: Ramelteon (RML) is a potent, selective agonist of the high-affinity melatonin receptor 1 and 2 receptors. In addition, RML is known to have antioxidant and anti-inflammatory effects. In this study, we aimed to investigate the effects of RML on HIF-1 alpha, VEGF and e-NOS signaling pathway in a rat model of endotoxin-induced uveitis (EIU).