Melatonin receptor agonist ramelteon alleviates experimental acute ocular inflammation via HIF-1 Alpha/VEGF/E-NOS signaling
EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol.33, no.2, pp.1018-1025, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 2
- Publication Date: 2023
- Doi Number: 10.1177/11206721221123878
- Journal Name: EUROPEAN JOURNAL OF OPHTHALMOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
- Page Numbers: pp.1018-1025
- Keywords: Ramelteon, melatonin analog, endotoxin-induced uveitis, inflammation, HIF 1 alpha, ENDOTOXIN-INDUCED UVEITIS, NITRIC-OXIDE, EXPRESSION, RAT
- Süleyman Demirel University Affiliated: Yes
Abstract
Purpose: Ramelteon (RML) is a potent, selective agonist of the high-affinity melatonin receptor 1 and 2 receptors. In addition, RML is known to have antioxidant and anti-inflammatory effects. In this study, we aimed to investigate the effects of RML on HIF-1 alpha, VEGF and e-NOS signaling pathway in a rat model of endotoxin-induced uveitis (EIU).