JOURNAL OF PERIODONTAL RESEARCH, vol.53, no.2, pp.258-266, 2018 (Peer-Reviewed Journal)
Article / Article
JOURNAL OF PERIODONTAL RESEARCH
Science Citation Index Expanded, Scopus
cholesterol, gingiva, inducible nitric oxide synthase, periodontitis, rosuvastatin, LIGATURE-INDUCED PERIODONTITIS, CHOLESTEROL-RICH DIET, ALVEOLAR BONE LOSS, GINGIVAL TISSUES, DNA-DAMAGE, SIMVASTATIN, INOS, 8-HYDROXYDEOXYGUANOSINE, PATHOGENESIS, MECHANISMS
Background and Objective: Nitric oxide is a free radical that is synthesized from L-arginine by nitric oxide synthase (NOS). The level of inducible NOS (iNOS) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL) and iNOS(+) cell counts in gingival tissues in rats with ligature-induced experimental periodontitis with/without hyperlipidaemia.