Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis


KIRZIOĞLU F. Y. , Ozmen O., Dogan B., Bulut M. T. , FENTOĞLU Ö., OZDEM M.

JOURNAL OF PERIODONTAL RESEARCH, vol.53, no.2, pp.258-266, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1111/jre.12513
  • Journal Name: JOURNAL OF PERIODONTAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.258-266
  • Keywords: cholesterol, gingiva, inducible nitric oxide synthase, periodontitis, rosuvastatin, LIGATURE-INDUCED PERIODONTITIS, CHOLESTEROL-RICH DIET, ALVEOLAR BONE LOSS, GINGIVAL TISSUES, DNA-DAMAGE, SIMVASTATIN, INOS, 8-HYDROXYDEOXYGUANOSINE, PATHOGENESIS, MECHANISMS

Abstract

Background and Objective: Nitric oxide is a free radical that is synthesized from L-arginine by nitric oxide synthase (NOS). The level of inducible NOS (iNOS) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL) and iNOS(+) cell counts in gingival tissues in rats with ligature-induced experimental periodontitis with/without hyperlipidaemia.