Cytotoxic activity properties of a benzimidazolium salt against lung, liver, and colon cancer cell lines
Journal of the Indian Chemical Society, cilt.101, sa.11, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 101 Sayı: 11
- Basım Tarihi: 2024
- Doi Numarası: 10.1016/j.jics.2024.101445
- Dergi Adı: Journal of the Indian Chemical Society
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, Chemical Abstracts Core
- Anahtar Kelimeler: Benzimidazolium salt, Cancer, Cytotoxic activity
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
In this study, a known benzimidazolium salt was synthesized in two steps starting from N-phenyl-o-phenylenediamine. This compound was tested in vitro for 72 h against different cancer cell lines (A549 - lung cancer, HepG2 - liver cancer, DLD-1 - colon cancer) and to compare the activity of this compound with cisplatin, a widely used chemotherapeutic agent. The evaluation of compound 4 as a potential anticancer agent against different cancer types was achieved by examining the cytotoxic effects of this compound through IC50 values using the MTT method. It was found that compound 4 showed different activity depending on the cell type and had a high cytotoxic effect (IC50: 15.68 μM), especially against lung cancer cell line for 72 h incubation time.