Circulating levels of ghrelin, galanin, and orexin-A orexigenic neuropeptides in obstructive sleep apnea syndrome

ÖZTÜRK Ö. , Cebeci D., ŞAHİN U. , EVGEN TÜLÜCEOĞLU E. , ŞAHİN CALAPOĞLU N. , Gonca T., ...More

SLEEP AND BREATHING, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1007/s11325-021-02514-w
  • Title of Journal : SLEEP AND BREATHING
  • Keywords: Obstructive sleep apnea syndrome, Ghrelin, Galanin, Orexin-A, Neuropeptides, OBESITY, LEPTIN, METABOLISM, RESISTANCE

Abstract

Purpose The orexigenic peptides, ghrelin, galanin, and orexin-A, have an important role in food intake and energy homeostasis and regulate the higher brain functions including the sleep-wake state. Although the interactions of these neuropeptides affect neuroendocrine systems resulting in obesity, a major risk factor for obstructive sleep apnea syndrome (OSAS), the mechanism has not been fully elucidated. The objective of this study was to evaluate the association of serum ghrelin, galanin, and orexin-A levels with OSAS.