Circulating levels of ghrelin, galanin, and orexin-A orexigenic neuropeptides in obstructive sleep apnea syndrome

ÖZTÜRK, Önder; Cebeci, Defne; ŞAHİN, Uğur; EVGEN TÜLÜCEOĞLU, Eda; ŞAHİN CALAPOĞLU, Nilüfer; Gonca, Taner; CALAPOĞLU, Mustafa

doi:10.1007/s11325-021-02514-w

Circulating levels of ghrelin, galanin, and orexin-A orexigenic neuropeptides in obstructive sleep apnea syndrome

ÖZTÜRK Ö., Cebeci D., ŞAHİN U., EVGEN TÜLÜCEOĞLU E., ŞAHİN CALAPOĞLU N., Gonca T., ...More

SLEEP AND BREATHING, vol.26, no.3, pp.1209-1218, 2022 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 26 Issue: 3
Publication Date: 2022
Doi Number: 10.1007/s11325-021-02514-w
Journal Name: SLEEP AND BREATHING
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, EMBASE, MEDLINE
Page Numbers: pp.1209-1218
Keywords: Obstructive sleep apnea syndrome, Ghrelin, Galanin, Orexin-A, Neuropeptides, OBESITY, LEPTIN, METABOLISM, RESISTANCE
Süleyman Demirel University Affiliated: Yes

Abstract

Purpose The orexigenic peptides, ghrelin, galanin, and orexin-A, have an important role in food intake and energy homeostasis and regulate the higher brain functions including the sleep-wake state. Although the interactions of these neuropeptides affect neuroendocrine systems resulting in obesity, a major risk factor for obstructive sleep apnea syndrome (OSAS), the mechanism has not been fully elucidated. The objective of this study was to evaluate the association of serum ghrelin, galanin, and orexin-A levels with OSAS.