Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum


KIRKAN B. , Sarikurkcu C., ÖZER M. S. , Cengiz M. , Atilgan N., CEYLAN O., ...Daha Fazla

INDUSTRIAL CROPS AND PRODUCTS, cilt.125, ss.549-555, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 125
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.indcrop.2018.09.043
  • Dergi Adı: INDUSTRIAL CROPS AND PRODUCTS
  • Sayfa Sayıları: ss.549-555

Özet

This study focused on phytochemical characterization and biological evaluation, both antioxidant and enzymatic inhibition, of ethyl acetate (OTT-EtOAc), methanol (OTT-MeOH), and water (OTT-W) extracts from Onosma tauricum var. tauricum aerial parts. The OTT-W extract was found to be the richest one in terms of its phenolic and flavonoid contents. Amounts of the phenolic and flavonoid compounds were determined as 40.88 mu mol GAEs/g and 7.40 mu mol REs/g dry plant (dp), respectively. The OTT-MeOH and OTT-W extracts were also found to contain significant amounts of chlorogenic acid, rosmarinic acid, p-hydroxybenzoic acid, caffeic acid, rutin, p-coumaric acid, trans-cinnamic acid, luteolin, and apigenin. The OTT-W extract showed remarkable antioxidant activity in phosphomolybdenum, ferrous ion chelating, reducing power, and radical scavenging assays. The OTT-MeOH extract exhibited inhibitory activity on acetylcholinesterase (AChE) (54.62 mu mol GALAEs/g dp), while the extracts remained almost inactive on butyrylcholinesterase (BChE). The OTT-W extract also exhibited inhibitory activity on tyrosinase (90.66 mu mol KAEs/g dp) and alpha-glucosidase (2258.87 mu mol ACEs/g dp). The results suggest that especially the OTT-MeOH and OTT-W extracts can be used as a source of alternative natural products in the treatment of diseases caused by the enzymes evaluated here.