Owing to the aging world population, medical problems due to old age significantly burden healthcare and economic systems. A major health problem in elderly individuals is loss of bone mass due to osteoporosis, a popular biomedical research subject. Current medical approaches to osteoporosis include pharmacological treatment options, with undesirable adverse effects resulting from many drugs. Alternative methods have been investigated to prevent bone-mass loss or increase bone mass. For example, pulsed electromagnetic field applications are well-studied modalities with varying results. Most studies on PEMF were conducted on postmenopausal women or ovariectomized rats, but epidemiological data suggest that osteoporosis in males is as crucial as in females. This study is the first to evaluate the PEMF effects on heparin-induced osteoporosis in male rats.