The comparative study of the DNA binding and biological activities of the quaternized dicnq as a dicationic form and its platinum(II) heteroleptic cationic complex


Yildiz U., Sengul A., Kandemir I., Comert F., AKKOÇ S., Coban B.

BIOORGANIC CHEMISTRY, vol.87, pp.70-77, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bioorg.2019.03.009
  • Journal Name: BIOORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.70-77
  • Keywords: DNA binding, Intercalation, Dicnq, Transcription inhibition, PCR inhibition, Cytotoxicity, Antibacterial susceptibility, MOLECULAR LIGHT SWITCH, TRANSCRIPTION INHIBITION, RUTHENIUM(II) COMPLEXES, COBALT(III), LIGANDS, 6,7-DICYANODIPYRIDOQUINOXALINE, DERIVATIVES, SELECTIVITY, CLEAVAGE

Abstract

The square-planar heteroleptic Pt(II) coordination compound [Pt(bpy)(dicnq)](NO3)(2) (1) and the quaternized dicnq ligand, namely 12,13-dicyano-5,6-dihydrodipyrazino[2,3-f:1',2',3',4'-lmn] [1,10] phenanthroline-4,7-diium dibromide (2) (Fig. 1) were synthesized and fully characterized by means of FTIR, NMR, MALDI-TOF MS and the purity was confirmed by CHN analyses. The DNA binding profiles of 1 and 2 were identified in an identical condition. The biological activities of these compounds were investigated by the assays of transcription and replication inhibition, cytotoxic and antimicrobial activity.