The comparative study of the DNA binding and biological activities of the quaternized dicnq as a dicationic form and its platinum(II) heteroleptic cationic complex


Yildiz U., Sengul A., Kandemir I., Comert F., AKKOÇ S. , Coban B.

BIOORGANIC CHEMISTRY, cilt.87, ss.70-77, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 87
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.bioorg.2019.03.009
  • Dergi Adı: BIOORGANIC CHEMISTRY
  • Sayfa Sayıları: ss.70-77

Özet

The square-planar heteroleptic Pt(II) coordination compound [Pt(bpy)(dicnq)](NO3)(2) (1) and the quaternized dicnq ligand, namely 12,13-dicyano-5,6-dihydrodipyrazino[2,3-f:1',2',3',4'-lmn] [1,10] phenanthroline-4,7-diium dibromide (2) (Fig. 1) were synthesized and fully characterized by means of FTIR, NMR, MALDI-TOF MS and the purity was confirmed by CHN analyses. The DNA binding profiles of 1 and 2 were identified in an identical condition. The biological activities of these compounds were investigated by the assays of transcription and replication inhibition, cytotoxic and antimicrobial activity.