The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells

Bayram D., Cetin E. S. , Kara M., Özgöçmen M., Candan I. A.

HUMAN & EXPERIMENTAL TOXICOLOGY, vol.36, no.6, pp.573-586, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1177/0960327116658105
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.573-586
  • Süleyman Demirel University Affiliated: Yes


Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown that silibinin inhibits experimentally induced malignancies of the liver, prostate, skin, and colon as well as promotes inhibition of the proliferation of cancer cell lines in vitro. This study aimed to investigate the effects of silibinin on the human breast carcinoma cell lines MDA-MB-231 and MCF-7 in monolayer and spheroid cultures.