Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol.33, no.6, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 6
- Publication Date: 2019
- Doi Number: 10.1002/jbt.22306
- Journal Name: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Süleyman Demirel University Affiliated: Yes
Abstract
The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active (K-i: 14 mu M) for hCA I and 3f (K-i: 126 mu M) for hCA II.