Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity

Rifati-Nixha, Arleta; ARSLAN, MUSTAFA; GENÇER, NAHİT; Cikrikici, Kubra; GÖKÇE, Başak; ARSLAN, OKTAY

doi:10.1002/jbt.22306

Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity

Rifati-Nixha A., ARSLAN M., GENÇER N., Cikrikici K., GÖKÇE B., ARSLAN O.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, cilt.33, sa.6, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 33 Sayı: 6
Basım Tarihi: 2019
Doi Numarası: 10.1002/jbt.22306
Dergi Adı: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active (K-i: 14 mu M) for hCA I and 3f (K-i: 126 mu M) for hCA II.