Oxidative Stress and Inflammation Markers in Lipopolysaccharide ( LPS)Induced Acute Kidney Injury in Rats-The Potential Role of Lacosamide
JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE, cilt.10, sa.8, ss.65-73, 2022 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 8
- Basım Tarihi: 2022
- Dergi Adı: JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.65-73
- Anahtar Kelimeler: Lacosamide, Lipopolysaccharide, Kidney injury, Oxidative stress, Inflammation, ACUTE-RENAL-FAILURE, IN-VITRO MODEL, GLUTATHIONE-PEROXIDASE, BIOLOGICAL MARKER, SEPSIS, MALONDIALDEHYDE, DYSFUNCTION, MORTALITY, PRETREATMENT, DEFINITIONS
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Background: Sepsis is a well-known cause of multiple organ failure although its molecular mechanism is not fully defined. In this study, antioxidant, and anti-inflammatory effects of lacosamide (LCM) on the kidney tissue of rats with sepsis were investigated in the experimental LPS-induced sepsis model.