Oxidative Stress and Inflammation Markers in Lipopolysaccharide ( LPS)Induced Acute Kidney Injury in Rats-The Potential Role of Lacosamide


ASLANKOÇ R., ÖZMEN Ö., KAVRIK O., Yalcin A.

JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE, vol.10, no.8, pp.65-73, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 8
  • Publication Date: 2022
  • Journal Name: JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.65-73
  • Keywords: Lacosamide, Lipopolysaccharide, Kidney injury, Oxidative stress, Inflammation, ACUTE-RENAL-FAILURE, IN-VITRO MODEL, GLUTATHIONE-PEROXIDASE, BIOLOGICAL MARKER, SEPSIS, MALONDIALDEHYDE, DYSFUNCTION, MORTALITY, PRETREATMENT, DEFINITIONS
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background: Sepsis is a well-known cause of multiple organ failure although its molecular mechanism is not fully defined. In this study, antioxidant, and anti-inflammatory effects of lacosamide (LCM) on the kidney tissue of rats with sepsis were investigated in the experimental LPS-induced sepsis model.