Background: Pain in the newborn child can be associated with various risks. For this reason, as well as for ethical reasons, it seems essential to find a simple and acceptable method for reducing pain. Pharmacological agents are not recommended because of their side-effects. Glucose and sucrose solutions were administered, and were found effective for pain relief in minor procedures in previous studies. Fructose solution has not been tried in human neonates before now. For this study, fructose solution for pain relief was tried during heel lancing in term neonates, and to compare its effect with glucose and placebo, using a validated behavioral acute pain rating scale.