Inhibin alpha and beta expression in ovarian stromal tumors and their histological equivalences

Ciris M., ERHAN Y., ZEKİOĞLU O., Bayramoglu H.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, vol.83, no.5, pp.491-496, 2004 (SCI-Expanded) identifier identifier identifier


Inhibin is a heterodimeric protein hormone that appears to be a sensitive immunohistochemical marker of sex cord-stromal tumors. Although sex cord-stromal tumors can usually be distinguished from ovarian epithelial tumors or their metastases by morphology or by using antibodies against intermediate filaments, the diagnosis remains difficult in rare situations in such cases as sarcomatoid granulosa-theca cell tumors, ovarian small cell carcinomas, or soft-tissue sarcomas. The purposes of this study were to examine inhibin alpha and beta immunoreactivity in a wide range of gonadal stromal neoplasms and to assess its value in the differential diagnosis of problematic tumors.