Characterization of calcium malic acid complex synthesized from Rhus coriaria and its protective effects on retinal pigment epithelial cells
Journal of Molecular Structure, cilt.1359, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1359
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.molstruc.2026.145486
- Dergi Adı: Journal of Molecular Structure
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC
- Anahtar Kelimeler: Degeneration, Malic acid, Rhus coriaria, Structural characterization
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Malic acid, a prominent organic acid in Rhus coriaria (sumac), a plant widely distributed in Türkiye and traditionally consumed as a food additive, serves as a key raw material across various industries. This study explores the structural features of a calcium complex derived from malic acid extracted from sumac leaves and evaluates its potential to mitigate oxidative damage caused by hydrogen peroxide (H₂O₂) in retinal pigment epithelial (RPE) cells. Characterization techniques include Spectroscopy, Nuclear Magnetic Resonance, Thermal Analysis, and Mass Spectrometry. Additional assessments covered electrochemical behavior, photoluminescence, and thermal stability. Furthermore, the complex's impact on AMD (Age-Related Macular Degeneration) was investigated using ARPE-19 cell lines, with results analyzed statistically. Our findings reveal that the naturally sourced calcium malic acid complex not only exhibits a well-defined structure but also confers protective effects against H₂O₂-mediated oxidative stress in RPE cells, suggesting its potential as a therapeutic agent for retinal disorders.