Chemometric Determination of Ezetimibe and Simvastatin Active Ingredients

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Ertokuş G.

in: New Trends in Technical, Natural Sciences, Engineering and Health Sciences, Prof. Qurban QUASIMOV,Ph.D. Assoc. Prof. Mirvari AGAYEVA, Editor, DUVAR YAYINLARI, Ankara, pp.25-32, 2022

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2022
  • Publisher: DUVAR YAYINLARI
  • City: Ankara
  • Page Numbers: pp.25-32
  • Editors: Prof. Qurban QUASIMOV,Ph.D. Assoc. Prof. Mirvari AGAYEVA, Editor


For a variety of factors, cardiovascular (heart and vascular) disorders are today’s and emerging main causes of mortality (death) and morbidity (incapacity) in countries. Furthermore, health has a significant influence in spending due to its direct and indirect expenses. In recent years, cardiovascular disease death rates have dropped dramatically in many European countries. Despite the fact that it has dropped, it is still the leading cause of mortality in Europe. In developing countries, more than 80% of deaths due to cardiovascular disease occur. It’s expected to happen (Narla et al. 2009, Uyar 2009, Perk et al. 2012). The behavior of society’s conservation programs aiming at change has had an impact on the lowering trend of cardiovascular disease in industrialized countries. Cardiovascular problems are linked to an unhealthy lifestyle and social environment, according to studies. (Arıkan et al, 2009). Cholesterol is separated into two categories: good cholesterol and bad cholesterol. The existence of benign cholesterol (HDL), which is important in the body and should be present in high amounts, is critical to our health. HDL aids in the transport of excess cholesterol from the body to the liver, where it is digested and eliminated through the digestive system. Because it slows blood circulation and removes cholesterol that causes vascular obstruction, HDL is regarded as “good cholesterol.” Malignant cholesterol (LDL), on the other hand, is a protein produced in the liver and transmitted through the bloodstream. In addition to being well-known, LDL has a number of favorable characteristics. When the transporter of antioxidants and amino acids to other cells, LDL (Güven A., 2005), is identified in excess in the human body, it has a negative influence on the body. As a result, early detection and treatment are crucial. The disorder is treated with drugs like ezetimibe and simvastatin. As a result, the concentrations of ezetimibe and simvastatin must be determined. In this study, UV spectroscopy data was used to make chemometric measurements of cholesterol medicines.