Residues from agricultural production are sources of raw material for biomass energy. Biogas technology allows organic waste/residues to be recovered. Safflower harvest residues (SHR) are resulted from safflower production. The purpose of this study is the assessment of the methane volume obtainable from SHR with dairy manure (DM) in the anaerobic fermentation process. Five mixtures of SHR and DM were prepared considering the mixing ratio (miR=SHR/(SHR+DM), dry basis, as 0.06, 0.27, 0.49, 0.74, and 1.0. Batch fermentation test was carried out in bioreactors made of eighteen 2-L flasks located in a temperature controlled water bath with a dimension of 80 x 60 x 20 cm. The mixing of each bioreactor was done by mechanical rotating mixers driven by motor coupled with 10 rpm output gearbox. During the experiment, methane (CH4), carbon, nitrogen, pH, EC, dry matter, and organic matter were measured. The results were presented in the study.