Izmir, the third largest city and a major economic center in Turkey, has more than three million residents and half million buildings. In this study, the seismic risk in reinforced concrete buildings that dominate the building inventory in Izmir is investigated through multiple approaches. Five typical reinforced concrete buildings were designed, modeled and assessed for seismic vulnerability. The sample structures represent typical existing reinforced concrete hospital, school, public, and residential buildings in Izmir. The seismic assessments of the considered structures indicate that they are vulnerable to damage during expected future earthquakes.