In this study, production routes of medical In-110,In-111 radio-nuclides produced by Cd-110(p, n)In-110, Cd-111(p, 2n)In-110, (112)cd(p, 3n)In-110, Ag-107(alpha, n)In-110, Ag-109(alpha, 3n)In-110, Cd-111(p, n)In-111, Cd-112(p, 2n)In-111, Cd-113(p, 3n)In-111, Cd-114(p, 4n)In-111, Ag-109(alpha, 2n)In-111, Ag-107(alpha, gamma)In-111 and In-113(n, 3n)In-111 reactions have been investigated up to 70 MeV incident particle energy. In these calculations, the pre-equilibrium and equilibrium effects have been investigated. The pre-equilibrium calculations involve the geometry dependent hybrid model and the cascade exciton model. The full exciton model has also been used to investigate the pre-equilibrium direct effects. Equilibrium effects are calculated according to the Weisskopf-Ewing model. The calculated results are compared with the experimental data taken from the literature.