EGF and FGF-2 infusion increases post-ischemic neural progenitor cell proliferation in the adult rat brain
NEUROSURGERY, cilt.57, sa.6, ss.1254-1262, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 6
- Basım Tarihi: 2005
- Doi Numarası: 10.1227/01.neu.0000186040.96929.8a
- Dergi Adı: NEUROSURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1254-1262
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
OBJECTIVE: Epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) play 1 a critical role in neurogenesis. In the present study, we evaluated the additive effect of administering these two factors on post-ischemic progenitor cell proliferation, survival, and phenotypic maturation in the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) in the adult rat brain after transient middle cerebral artery occlusion.