EGF and FGF-2 infusion increases post-ischemic neural progenitor cell proliferation in the adult rat brain

Tureyen K., Vemuganti R., Bowen K., Sailor K., Dempsey R.

NEUROSURGERY, vol.57, no.6, pp.1254-1262, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1227/01.neu.0000186040.96929.8a
  • Journal Name: NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1254-1262
  • Süleyman Demirel University Affiliated: No


OBJECTIVE: Epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) play 1 a critical role in neurogenesis. In the present study, we evaluated the additive effect of administering these two factors on post-ischemic progenitor cell proliferation, survival, and phenotypic maturation in the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) in the adult rat brain after transient middle cerebral artery occlusion.