In this study, we select naproxen (NAP) as a reference drug and electrospun poly (epsilon-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with betacyclodextrin (beta CD) to form inclusion complex (NAP-beta CD-IC) and then NAP-beta CD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-beta CD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-beta CD-IC and the presence of CD-IC in PCL/NAP-beta CD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-PCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300 nm, in addition, the aggregates of CD-IC in PCL/NAP-beta CD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-beta CD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC. (C) 2013 Elsevier B.V. All rights reserved.