miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K

GÜRBÜZ, Nilgün; Kahraman, Nermin; Sonmez, Hafize; Mokhlis, Hamada; ASLAN KOŞAR, Pınar; Ozpolat, Bulent

doi:10.2174/1871520622666220117123213

miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K

GÜRBÜZ N., Kahraman N., Sonmez H. E., Mokhlis H. A., ASLAN KOŞAR P., Ozpolat B.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.22, no.14, pp.2607-2618, 2022 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 22 Issue: 14
Publication Date: 2022
Doi Number: 10.2174/1871520622666220117123213
Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
Page Numbers: pp.2607-2618
Keywords: Pancreatic cancer, miRNA, miR-193b, EMT, eEF2K, proliferation, metastasis, PROMOTES PROLIFERATION, PROTEIN-KINASE, MICRORNAS, EXPRESSION, PROGRESSION, TUMORIGENESIS, METASTASIS, APOPTOSIS
Süleyman Demirel University Affiliated: Yes

Abstract

Background: Pancreatic ductal adenocarcinoma ( PDAC) is the 4th leading cause of cancer deaths in the US due to the lack of effective targeted therapeutics and extremely poor prognosis.