Aim: This study aims to determine the advantages and the disadvantages of single-incision laparoscopic surgery (SILS) and standard laparoscopic cholecystectomy by comparing the cases of these two techniques. Material and Method: Between September 2010 and June 2013, the datas of 80 patients with laparoscopic cholecystectomy were studied retrospectively. Operations were seperated into 2 groups that were SILS and standard laparoscopic surgery. Each group consisted of 40 randomly chosen patients. The age, sex, weight, height, body mass index, American Society of Anesthesiologists score (ASA), duration of operation, postoperative duration of hospital stay, need for surgical drain, infection injury, and postoperative need for analgesic of the patients were recorded. SPSS 21 was used analyzing these datas. Results: Operation period was signaficiantly short in SLK technic (p=0,001). Duration of staying hospital was statisticaly short in SLK technic (p=0,001). There was no complication except for wound infection and intraoperative bleeding. Complications were seen more in TILC group but they had not have statistically significiant (p=0,238). Although first cholecystectomy with TILC technic last 144 minute latest operation finished in just 48 minute. Discussion: Operation period and staying hospital in the single incision laparoscopic cholecystectomy' group has been founded statistically high. Operation period has been reduced thanks to experiences. There has no significant difference about complications. Demonstrating effectiveness and safety, and determinig low complication rises will provide development of technic.