TRPV1 Channel: A Potential Drug Target for Treating Epilepsy


Naziroglu M.

CURRENT NEUROPHARMACOLOGY, cilt.13, sa.2, ss.239-247, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1570159x13666150216222543
  • Dergi Adı: CURRENT NEUROPHARMACOLOGY
  • Sayfa Sayıları: ss.239-247

Özet

Epilepsy has 2-3% incidence worldwide. However, present antiepileptic drugs provide only partial control of seizures. Calcium ion accumulation in hippocampal neurons has long been known as a major contributor to the etiology of epilepsy. TRPV1 is a calcium-permeable channel and mediator of epilepsy in the hippocampus. TRPV1 is expressed in epileptic brain areas such as CA1 area and dentate gyrus of the hippocampus. Here the author reviews the patent literature on novel molecules targeting TRPV1 that are currently being investigated in the laboratory and are candidates for future clinical evaluation in the management of epilepsy.