Functional components, antidiabetic, anti-Alzheimer's disease, and antioxidant activities of Salvia syriaca L.

Bahadori M. B. , Dinparast L., Zengin G., Sarikurkcu C., Bahadori S., Asghari B., ...Daha Fazla

INTERNATIONAL JOURNAL OF FOOD PROPERTIES, cilt.20, sa.8, ss.1761-1772, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Konu: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/10942912.2016.1218893
  • Sayfa Sayıları: ss.1761-1772


Antidiabetic, anti-Alzheimer, general toxicity, and antioxidant activities of Salvia syriaca were evaluated. Phytochemical composition of the essential oil and methanolic extract of the plant were identified using gas chromatography-mass spectrometry and reverse-phase high-performance liquid chromatography-diode array detector techniques, respectively. Essential oil of S. syriaca exhibited strong cytotoxicity, antioxidant, a-amylase, and a-glucosidase inhibitory activities. Gas chromatography-mass spectrometry analysis showed that spathulenol (87.4%), isospathulenol (7.6%), and bornyl acetate (2.7%) are the major compounds in essential oil. High-performance liquid chromatography analysis indicated that rutin, quercetin, apigenin, rosmarinic acid, and ferulic acid are the most abundant phenolic components. S. syriaca could be considered as a valuable source of bioactive natural compounds for functional foods, medical, and pharmaceutical applications.