Variations in the origin of axillary artery branches are one of the most common variations. However, derivation of profunda brachii artery from circumflex humeral artery is a rare occurrence. Since it is a frequent site of injury and it is involved in many surgical and invasive procedures, the arterial variations in the arm is important for a clinician. During routine dissection, for students of medical school, a variation of profunda brachii artery was observed in right upper extremity of 62 year old male cadaver. In the present study, profunda brachii artery arose from posterior circumflex humeral artery and radial nerve in radial sulcus did not accompany profunda brachii artery. Awareness of details of variations of the axillary artery may function as a beneficial guide for vascular surgeons. It may contribute to preventing complications during the surgery of the axilla region.