A Case Series of Obstructive Prosthetic Mitral Valve Thrombosis, Successfully Treated with Low-Dose, Slow Infusion Tissue-Type Plasminogen Activator

ARI H., DOGAN A., Ceviker K., AKSOY F., ARSLAN A., VAROL E.

JOURNAL OF HEART VALVE DISEASE, vol.24, no.3, pp.353-359, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2015
  • Journal Name: JOURNAL OF HEART VALVE DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.353-359
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background and aim of the study: Prosthetic valve thrombosis (PVT) is a rare but serious complication of the prosthetic heart valve. Although recent guidelines generally recommend surgical treatment as the main option for patients with obstructive left sided PVT, thrombolytic therapy (TT) may offer another attractive approach. There is also no consensus on the type, dose and route of administration of thrombolytic agents. The present study included a small series of patients with low dose, slow infusion tissue-type plasminogen activator (tPA) to treat PVT in the mitral position.