Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa

ULUSOY, Seyhan; ŞENKARDEŞ, SEVİL; Coskun, Inci; Bosgelmez-Tinaz, Gulgun; Soulere, Laurent; Queneau, Yves; KÜÇÜKGÜZEL, ŞÜKRİYE

doi:10.2174/1570180814666161121120719

Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa

ULUSOY S., ŞENKARDEŞ S., Coskun I., Bosgelmez-Tinaz G., Soulere L., Queneau Y., ...Daha Fazla

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.5, ss.613-618, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 5
Basım Tarihi: 2017
Doi Numarası: 10.2174/1570180814666161121120719
Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.613-618
Anahtar Kelimeler: Celecoxib, sulfonylthioureido, 4-thiazolidinone, LasR protein, Pseudomonas aeruginosa, quorum sensing, BACTERIAL COMMUNICATION, INFECTIOUS-DISEASES, BIOFILM, DRUGS, IDENTIFICATION, VIRULENCE, MUTANT
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Background: A series of novel N-(substituted aryl/alkylcarbamothioyl)-4-[5-(4-methylphenyl)3-( trifluoromethyl)-1H-pyrazol-1-yl] benzene sulfonamides [SGK 318, 319, 320, 324, 327] and N-(3-substitutedaryl/ alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamides[SGK 328, 329, 330, 334, 337] were synthesized and tested for their quorum sensing inhibitor (QSI) capacity using quorum sensing inhibitor selector 1 (QSIS1) bioassay.