Amyloidosis is characterized by accumulation of amorphous, proteinaceous material in various organs and tissues of the body Amyloid goiter is an extremely rare pathologic condition due to massive amyloid infiltration of the thyroid tissue. Clinically significant thyroid involvement is found in only a small percentage of cases, although a finding of amyloid deposit in autopsies is not infrequent. We present a case of amyloid goiter The patient was diagnosed with rheumatoid arthritis 10 years previously and hospitalized for nephrotic levels of proteinuria. She was referred to our department for a rapid, painful growth in the thyroid gland. The patient finally underwent thy roidectomy due to progressive growth of the thyroid gland with compressive symptoms. In her thyroid pathology specimens there were amyloid deposits in the the entire thyroid tissue and in the arteriolar wall of parathyroid gland which was located intrathyroid.