Gadolinium chloride attenuates aortic occlusion-reperfusion-induced myocardial injury in rats


KIRIS I. , OKUTAN H., Savas C. , YONDEN Z., DELIBAS N.

SAUDI MEDICAL JOURNAL, cilt.28, ss.347-352, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 3
  • Basım Tarihi: 2007
  • Dergi Adı: SAUDI MEDICAL JOURNAL
  • Sayfa Sayıları: ss.347-352

Özet

Objectives: Aortic ischemia and reperfusion periods, which are often associated with infrarenal abdominal aortic cross-clamping and declamping, cause injury in distant organs including the heart. We recently reported that Kupffer cell blockage with gadolinium chloride (GdCl3) attenuates lung injury induced by aortic ischemia-reperfusion (IR). Therefore, we hypothesized that GdCl3 may attenuate myocardial injury induced by aortic IR.