Gadolinium chloride attenuates aortic occlusion-reperfusion-induced myocardial injury in rats


KIRIS I. , OKUTAN H., Savas C. , YONDEN Z., DELIBAS N.

SAUDI MEDICAL JOURNAL, vol.28, no.3, pp.347-352, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2007
  • Title of Journal : SAUDI MEDICAL JOURNAL
  • Page Numbers: pp.347-352

Abstract

Objectives: Aortic ischemia and reperfusion periods, which are often associated with infrarenal abdominal aortic cross-clamping and declamping, cause injury in distant organs including the heart. We recently reported that Kupffer cell blockage with gadolinium chloride (GdCl3) attenuates lung injury induced by aortic ischemia-reperfusion (IR). Therefore, we hypothesized that GdCl3 may attenuate myocardial injury induced by aortic IR.