GREEN SYNTHESIS OF GOLD NANOPARTICLES USING PRUNUS CERASUS L. LEAVES EXTRACT AND STUDY OF THEIR CYTOTOXIC EFFECT ON LIVER CELL LINE PRUNUS CERASUS L. YAPRAK EKSTRAKTINI KULLANARAK ALTIN NANOPARTİKÜLLERİNİN YEŞİL SENTEZİ VE KARACİĞER KANSERİ HÜCRE HATTI ÜZERİNDE ANTİPROLİFERATİF ETKİLERİNİN ARAŞTIRILMASI
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.49, sa.3, ss.870-877, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.33483/jfpau.1652814
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.870-877
- Anahtar Kelimeler: Antiproliferative activity, AuNPs, biosynthesis, Prunus cerasus L
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Objective: Gold nanoparticles (AuNPs) possess unique chemical, physical and biological properties that make them valuable in nanotechnology applications such as drug delivery, biosensor and photothermal therapy. This study aims to synthesize AuNPs using Prunus cerasus (P. cerasus) leaves extract as a green reducing and stabilizing agent and to evaluate their structural and biological properties. Material and Method: Green synthesis of AuNPs using P. cerasus leaves extract. The obtained AuNPs were characterized using UV-Vis spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and zeta potential analysis to evaluate their structural, morphological and stability properties. Result and Discussion: TEM analysis confirmed that the synthesized AuNPs were predominantly spherical and had an average size of 33±13 nm. Furthermore, the synthesized AuNPs were determined to have high stability by zeta potential analysis. Biological evaluations showed that AuNPs exhibited selective cytotoxic effects, approximately three times higher antiproliferative activity against liver cancer (HepG2) cells compared to P. cerasus leaves extract. These findings emphasize the potential of P. cerasus extract-mediated AuNPs for cancer treatment, supporting their applications in biomedical nanotechnology.