Discovery of new antidepressant agents: In vivo study on Anthemis wiedemanniana Fisch & Mey

Derelia F. T. , İlhan M., AKKOL E.

JOURNAL OF ETHNOPHARMACOLOGY, vol.226, pp.11-16, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 226
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jep.2018.07.019
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.11-16
  • Keywords: Anthemis wiedemanniana, Antidepressant, Asteraceae, Forced swimming test, Tail suspension test, SESQUITERPENE LACTONES, HEDYOSMUM-BRASILIENSE, TRADITIONAL MEDICINE, FOLK MEDICINE, ESSENTIAL OIL, TURKEY, MICE, L., DEPRESSION, ASTERACEAE
  • Süleyman Demirel University Affiliated: No


Ethnopharmacological relevance: Many of the currently available antidepressants have serious adverse effects and are also expensive. Traditional medicines are major sources of original drugs, and their role in effective treatment is remarkable. In Turkish folk medicine, decoctions and infusions are prepared from the flowers of Anthemis wiedemanniana Fisch. & Mey. They exert antispasmodic and sedative effects and are also used for treating urinary inflammations. The present study was designed to evaluate the antidepressant activity of A. wiedemanniana, which is used against central nervous system disorders in Turkish folk medicine.